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Cycling Again After DE Failures - Part 3?

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oh the cycling again thread is quiet.


I noticed that the part 2 thread is “closed to comments” – is it because it reached the limit for comments?


Hope everyone is well!


Sprightly, is your baby due soon? How are things?


Evening, how far along are you now?


Jly, any updates?


I haven’t posted in a while.


I have news…we had one PGS double donor embryo left from our fresh cycle early last year. After filling out international adoption papers and paying the agency’s registration fees, we decided to go ahead and still transfer our remaining embryo.


We are now almost 17 weeks pregnant. I have not wanted to announce anything to anyone because I just keep waiting for the ball to drop given our history. But my 8th (or maybe 9th, I’ve lost track) DE transfer seems to have worked.


I had a bad bleed at 12 weeks and thought it was another miscarriage, but it was a subchorionic hematoma, which is shrinking (now about 1.6 cm – small).


I am very excited but also very wary. I have a great midwife and a backup MFM doc.


Our protocol…


I went rouge on a couple of things. My RE wanted to do an ERA but we weren’t willing to put in the extra time or money given that we had pretty much settled on adoption. But, I remember my most successful pregnancies that went to a heartbeat were afternoon transfers, so I technically had been on progesterone for an extra 10 hours or so. So, I took fate into my own hands and did an extra 12 hrs of progesterone prior to transfer.


I also got my functional medicine doctor to prescribe low dose naltrexone (4.5mg), which is supposed to balance your immune system and reduce the chances of repeat miscarriage with very little side effects. My immunologist refused to prescribe it. https://www.ldnresearchtrust.org/sites/default/files/Dr_Phil_Boyle.pdf


I had been on prednisone for several months because of a previous transfer that didn’t take. I did 20mg of prednisone leading up to transfer and 30 mg at 11 weeks when my immune system flared up. I am still on 30 mg and my last immune labs were somewhat normal.


IVIG every 2-3 weeks – immunologist would prefer every 1-2 weeks but I couldn’t afford that. I am not sure if I need to continue it at this point but my last infusion was last week.


Vaginal Viagra prior to transfer, and a endometrial scratch the month prior (which was way more painful than any other scratch I had done, not sure why)


Baby aspirin, vit E, lovenox 40mg twice daily (now every other day after bleed), high doses of progesterone (2cc pio + 200mg prometrium three times daily); high doses estrogen (2mg estradiol three times a day plus estradiol patches, 2 every other day) – my progesterone/estrogen levels never cooperated (even yet) so they kept increasing my dosages, and I am still taking some progesterone and estrogen at 17 weeks.


High doses of methylfolate (I have a double mutation of C677T). I started out on Metanx but my B12 and B6 levels got too high, so they changed it to just 5mg of methylfolate.


Fish oil and curcumin for inflammation.


Lots of acupuncture, and I did some Chinese herbal teas for the immune system and inflammation prior to transfer.


 


 


 


 


Need Advice! Would you transfer 2 after unsuccessful round of DE IVF?

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I've been pursuing donor egg IVF and I'm working with a clinic that has 65-80% success rates with DE. I found a donor who was young (26) and proven (4x success). We did a freeze-all cycle with PGS testing. Consequently, we were lucky enough to end up with 8 normal frozen embryos.


When we went to do the first transfer, the first embryo didn't expand after thawing and the second embryo that they embryologist thawed also looked iffy. The clinic said that in their many years of doing this, they rarely see 5AA, super high quality blasts like this not expand after thaw. I transferred the second embryo since it looked a little better than the first one (that had some compromised cell structures after thaw). We knew that it would likely lead to a negative and were prepared for the worst. As expected, it was a BFN and we can clearly blame the failure on the fact that the embryo did not expand after thaw. Embryo expansion after thaw apparently is the number one determining factor of success rates with FETs.


Now, I'm concerned that since both blasts did not expand that we might just have a bad set of embryos. There is not male factor issues and the donor went on to have her own baby right after cycling for us so we know there are no egg issues.


But this makes no sense since all eight of the blastocysts were all graded 5AB or 5AA before being frozen. The clinic thinks it's a fluke and the previous couple this happened to several years ago went on to be successful with their second transfer (after they thawed 2 embryos in a row that didn't expand during their first DE IVF).


My question is if I'm just really concerned about embryo quality should I just transfer two embryos next time instead of one? Alternatively, I can thaw one embryo and if it expands then just do an eSET. If it doesn't expand perfectly in the morning, the embryologist could thaw another one and then transfer the two. 


I just don't know what to do since it seems like we've done everything possible to increase our chances of success and we've ended up on the very unlucky side here.


The embryologist says that if I transfer one expanded blast, I have a 65% chance of pregnancy. However, if I transfer two embryos, I have an 80% change of pregnancy with a 50% chance of twins. I think I'm just getting anxious and antsy and want to transfer two because I don't know how many more times I can keep doing this.


What would you do?

Gifts for our donor?

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Our retrieval is this Friday and DH and I wanted to get our donor something. It’s anonymous so we will leave with the dr to give to her. I’m thinking a pretty card, nice bottle of wine and chocolates? Did you guys get your donor a gift? She just got $5k so I’m not getting her anything crazy but we do want to show her how much we appreciate her.

TTC

What else to do

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Hello, I'm asking my self why it's not working and what else I have to do? Well after my loss in Dec 2016 and a D&C I tried to get pregnant again but has been so hard for me. I choose a different donor because she was my choice since the beginning and because she is proven and with positiveness both times with twins. So my first try BFN and then I though OK first time it's fine it can happen but then I tried on the first of Feb and again BFN so now I'm here all confuse what's going on with me, as far I know my only problem it's blocked tube but never knew of anything wrong with my uterus. I will have my consult with Doctor next week so if you please give me ideas of what to ask or what to do so I can keep trying with better results...... Sorry for the long post but at this point I'm desperate.

Awesome Friend

Blood type question

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So I finally picked a donor and she just had her medical screen. Yay! Only a couple more hurdles until they clear her!

Turns out she as well as my sperm donor and me are different blood types! I knew the sperm donor was different but my donor is a first time donor( I know, I know) so it wasn’t listed.

Does anybody know if this could be a potential issue? Luckily we are all rh+.


Thanks!

Does Donor age matter?

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So I finalized a donor. Thanks to all the ladies here who motivated. We are still in the process of finalizing on the donor. I loved her profile. We are ethnically different and yet so similar. She has great educational background and has a daughter and son of her own as well. The only thing is that she is 30 not 25-27 range, the usual that everyone goes for. My gut is saying she is the one but my DH has this nagging thing going right now, that she is old. :(


From your experience here, could you share if donor age matters? Did anyone have a donor who was 29/30 or above.

Secret Snowflake 2017TTCInfertility AwarenessBaby Wishes

xferred 2 3 day last week

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beta is tomorrow. i got a faint positive line . im excited but still waiting for beta tomorrow

Anyone have experience with Dr Jonathan Scher?

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At the advice of my RE I'm going to make an appointment with Dr Jonathan Scher after my 3rd failed donor egg transfer. I'm

slightly concerned because he seems to be an ob/gyn and his specialty seems to be RPL. I have had 3 miscarriages as well but they were due to chromosomal issues related to old eggs. But I'm wondering if he really has experience with failed implantation and possible immune causes. I see some info online saying he prescribes intralipids which makes me wonder why my RE (at RMA NY) is advising me to see him since doesn't seem to buy into immune issues. Anyway just wanted to see if any ladies had any words of wisdom or encouragement or warning ha.

egg donor , does race matter?

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Hi Ladies!


IVF is expensive


I'm 41, have 4 kids from previous marriage, 3 with issues, autism, although high functioning. Im a newlywed. My new husband has no children. Found out my tubes are blocked. I want an egg donor due to having 3 kids on spectrum. Makes sense right?


Shady grove wants 30k for egg donor cycle and will only transfer 1 embryo since I've had 4 sections. I cant afford that. And being that I dont have a history of losses, I said to my self, I know first try will work.


CNY wants 9k for donor egg cycle and will xfer 2 embryos.


Im black and 5'2", hubby is white and 5'11". CNY has 4 black donors all 5'7" to 5'11". I dont want a child , if a girl, that tall. So I chose a biracial girl that is 5'4". Hubby wants a child as dark as possible. He's imagining "scary spice", Halle berry, rihanna etc


Now i made a friend, she is black as well, in GA, hubby is white, IVF clinic in GA has no black donors, she chose a white donor and the clinic asked if she "was Sure"


I made another friend. Couple is Asian. No Asian donor at her clinic. So she is going to use white egg donor.


to me. families adopt across racial lines, all the time. 


lets be adults, no negative comments, but healthy discussion, for or against donor of different race


 

Anxiety over choosing the right Donor from frozen eggs

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This is our absolute final attempt at having a child. We are using DEB like we did last cycle. Last cycle we got 6 eggs and only 3 fertilized. We had a day 3 transfer of 1 grade A 8 cell embryo. The others didn’t make it and I ended up not having it implant. I’m having such anxiety picking a donor this time. Last time we went with a proven donor so I’m only looking for a proven donor again but knowing this is absolutely it terrifies me and makes the decision so much harder. Any advice ladies? My husband has left it all up to me this time and last.

Good quality 5d embryo or high quality 6d embryos

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I am coming out from lurching to ask anyone's take on my dilemma: I am adopting embryos and have been proposed a set of 6 6-day "high quality" embryos or a set of 6 5-day "good quality" embryos.  Both sets equally meet my personal criteria (physical characteristics)


From the literature I can find there seems to be conflicting results with 5d and 6d fet. Some say no difference at all others say that the 6d have less chance because they were a day late making envied blastocyst status.


When I search for anecdotal information there seems to be plenty of success stories with 6d fet.


If you were faced with making a decision would you favor the 5 day blasts even though marked "good" or the 6 day blasts considered "high quality"?  Or am I really splitting hairs and should just make a decision already and do the most important thing RELAX?


Thanks in advance for ideas.

Anyone use Donor Egg Bank USA???   

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Hi All


 


First time post but not new to IVF.  We started our journey March last year (2016) at me age 42.  First IVF (in vitro fertilization) 5 eggs, 3 - 3 day embryos, none made it to blast.  Second IVF (in vitro fertilization) (Aug 2016) - 5 eggs, 3 - 3 day embryos, 1 made blast and genetic testing says it had trisomies.  I'm 43 now....Third IVF (in vitro fertilization) (Nov 2016) - 7 eggs, 4 - 3 day embryos, 1 made blast and genetic testing says it had monosomies.  Dr suggests donor.  


 


We are committed to donor eggs but financially we are in for 60k plus on the last procedures with no prego.  So we are looking at the Egg Donor Bank, USA.



Anyone have success or failures with them?  Please tell me the details.  


 


There are 3 plans:

1) Trying to decide: Egg Lot - for $14,000 and done ny my own Doctor (IVF & FET costs added on).  


 


Or 


 


2) Single Cylce Plan - egg lot with discount plus all egg tham & embroyo transfer...etc.  Extra embroyos more to save for later.  This is $19,000 and only with selected clinics (not my clinic) but a clinic close by - San Diego Fertility.  Anyone use them?


 


3) Assured Refund Plan - you get up to 6 embryo transfers and if a live baby does not happen you get 100% refund.  So 6 lots of eggs and it includes everything from the fertilization and the FET transfers, etc.  refund option - $45,500


 


Can someone let me know their experience with DEB and San Diego Fertility or just Donor Egg Bank?  Thanks a million and baby dust.  XX

Frozen eggs - how many embryos?

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For those who used a frozen egg cohort, how many embryos did you get? We purchased a 6 egg cohort, curious what the stats are as far as embryo count.

TTCAwesome FriendLife of the PartyLurker

Anyone have experience with Dr Jonathan Scher?

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At the advice of my RE I'm going to make an appointment with Dr Jonathan Scher after my 3rd failed donor egg transfer. I'm

slightly concerned because he seems to be an ob/gyn and his specialty seems to be RPL. I have had 3 miscarriages as well but they were due to chromosomal issues related to old eggs. But I'm wondering if he really has experience with failed implantation and possible immune causes. I see some info online saying he prescribes intralipids which makes me wonder why my RE (at RMA NY) is advising me to see him since doesn't seem to buy into immune issues. Anyway just wanted to see if any ladies had any words of wisdom or encouragement or warning ha.

How soon is too soon?

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Hello. I’m not sure if this is the appropriate group for my question — if not, kindly direct me to a better group for it.


This may be too soon, but im already thinking about donor eggs after one failed pregnancy and one failed IUI. I don’t think I have what it takes to go through the brave journeys I have read about in several of the groups here.


I am 38 years old and stupidly allowed fears and concerns about my career and my husband’s career to delay my family dreams.


When we finally were ready, I actually got pregnant on the second try last fall only to discover an empty sac on the ultrasound at 11 weeks, with no other symptoms, but there was a concern that I could have been a molar pregnancy —The worst day of my life. I had a D&C, waited two long weeks to get the tissue sample results saying it was not molar — and my obgyn just told me I’m fine, I’m fertile, and to go try to conceive again in three months.


Instead I went to a specialist and found out I had a cyst on an ovary and very low AMH (0.03). I was monitored for a while until the cyst was gone, my period came back, and it appeared I had ovulated in my own. I was then put on injectables and scheduled for an IUI. Everything seemed to be going so well until today — my test was negative.


I haven’t met with the doctor yet to hear his thoughts on this failed IUI, but I know he had already told us IVF was not an option because with my low egg reserve it would be too much and backfire. But he didn’t think egg quality was an issue (not sure how he can even tell :( ) His original plan was to keep trying these medicated IUIs until one works.


So the first one has failed and I know that is common but I am so upset and wondering if I should even bother trying again with my own eggs. I don’t know much about the donor egg process but I do know that I have no reservations about trying it if it means I can be a mom. I don’t care about having a genetic link — I can definitely get over that quickly.


But my husband wants to exhaust all other options first. However, this would come at a great cost to me, since I am so fragile and so deeply troubled that I just don’t think I can tolerate it. I admire the women that keep moving forward, but I think I’m just not that woman. It’s a personality flaw, perhaps. For example in the past, when things weren’t working out for me at a job, I moved on to another job. Even as a kid, I never followed through with a sport if I didn’t meet with success right away. I never had to study much because I was a naturally good student. I am starting to realize I simply don’t have the skill set and mental and emotional stamina to do this.


Meanwhile it seems that my life and relationships are on hold since the miscarriage, and I don’t enjoy anything. Some days, like today, I don’t have the will to live and although I would never harm myself, I find myself thinking I wouldn’t mind at all if I failed to wake up tomorrow. I just want my life back, and it feels like the only way is with a baby. Nothing will ever be meaningful until then.


Oh boy, I just realized how terribly depressing my post is! I’m sorry — back to my original question. How soon is too soon to be considering donor eggs? Because in addition to feeling hopeless about more procedures, I am also worried that if I wait too long I will end up in menopause and get no shot at a baby at all — my mom had premature menopause at 39.


I am also afraid of missing out if I don’t get myself moving with research at the very least. Are there long wait lists? I don’t want to make the decision and then be told I have to wait another year or something for a donor. We briefly looked at adoption, but for infants it seems that the wait is several years.


So is it too soon to be thinking about this, or should I start working on finding a donor? How long does it take? How likely are my odds if I do wait another year? Two years?


Are there any serious questions I should be asking myself first?


Of course, I won’t make any rash decisions right now, but I would like an action plan or time line to consider.


I probably sound like I’m whining, having only been on this journey about 8 months compared to the amazing women that have endured years of treatments and waiting, but I am simply not that strong — please forgive me, I don’t mean to be insensitive.


Since my miscarriage, I have sought counseling, prayer, meditation, yoga, acupuncture, massage, and have eaten pretty much all organic with fistfuls of vitamins and supplements. I haven’t had alcohol since first finding out I was pregnant in the fall and I gave up all caffeine (even decaf) after the miscarriage. I changed most of my cosmetics and cleaning products to natural ones and stopped using plastics last summer. I’ve read several books on egg quality and have been trying as many of the recommendations as possible. But this lifestyle is all consuming and I don’t know if I can keep it up.


Thank you for your thoughts and kindness.

Anyone use Donor Egg Bank USA???   

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Hi All


 


First time post but not new to IVF.  We started our journey March last year (2016) at me age 42.  First IVF (in vitro fertilization) 5 eggs, 3 - 3 day embryos, none made it to blast.  Second IVF (in vitro fertilization) (Aug 2016) - 5 eggs, 3 - 3 day embryos, 1 made blast and genetic testing says it had trisomies.  I'm 43 now....Third IVF (in vitro fertilization) (Nov 2016) - 7 eggs, 4 - 3 day embryos, 1 made blast and genetic testing says it had monosomies.  Dr suggests donor.  


 


We are committed to donor eggs but financially we are in for 60k plus on the last procedures with no prego.  So we are looking at the Egg Donor Bank, USA.



Anyone have success or failures with them?  Please tell me the details.  


 


There are 3 plans:

1) Trying to decide: Egg Lot - for $14,000 and done ny my own Doctor (IVF & FET costs added on).  


 


Or 


 


2) Single Cylce Plan - egg lot with discount plus all egg tham & embroyo transfer...etc.  Extra embroyos more to save for later.  This is $19,000 and only with selected clinics (not my clinic) but a clinic close by - San Diego Fertility.  Anyone use them?


 


3) Assured Refund Plan - you get up to 6 embryo transfers and if a live baby does not happen you get 100% refund.  So 6 lots of eggs and it includes everything from the fertilization and the FET transfers, etc.  refund option - $45,500


 


Can someone let me know their experience with DEB and San Diego Fertility or just Donor Egg Bank?  Thanks a million and baby dust.  XX

3rd attempt donor egg transfer

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Hi all,


After total 4 ivfs, 2 with my own eggs (failed due to low amh) and two with donor eggs. I concieved with the first DE cycle but miscarried at 9 weeks due to large yolk sac and 2nd cycle with frozen embryo of same donor failed.


Now, I am going for the third cycle with DE of new donor. 


Very afraid and nervous as I feel this is my last attempt with IVF. My DH is also ready for adoption which we may go after this.


Does any of you have similar story to share?

Fall 2017 DE Transfers

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Starting a thread for those of us having DE IVF transfers September, October or November 2017 to share our journeys/offer support to others as we hopefully bring home a baby. 

To implant one or two?

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Hi ladies, I am 45 and want to move forward with donor eggs. I have two kids from a previous marriage and would love to have more. I had one miscarriage 15 months ago after a natural pregnancy and have had two failed IUI’s using follostim since. I am apparently not a candidate for IVF. The doctors at the clinic we are using strongly advise against implanting more than one embryo at a time, especially at my age. I want to maximize my chances of getting pregnant and would love to have twins (too crazy?)! I don’t want to do anything that would put my potential babies or myself at risk. I figure I will just follow their advice ultimately but wonder what you all think and if you have experiences you would like to share. Thank you

HCG rising after stopping meds?!?

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Seriously. This cycle is so nutty.


FET 2/22.

HCG on 3/6 was 21

HCG on 3/8 was 36.


Stopped all meds 3/8

Some bleeding noted. No other symptoms.


HCG today 3/12 was 99. WTH??


Now I have to have an U/S on Wednesday to check things out. Im pretty sure nothing is viable at those levels and all this is doing is prolonging my next attempt. Ugh.


Anyone else ever have this??

RainbowInfertility Awareness

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