Some of you may have seen some of what I'll post here in the Early/Mid 2014 thread - apologies for any repetition.
I've had 8 first-tri losses, two before our son was born in 2012 and 6 since 2013(including one perfect 4AA DE blast and OE IVF and OE IUI chemical pregnancies). I had the RPL panel, including MTHFR, and karyotype testing (LP had karyotype done too) in early 2013, all test results normal.
I have asthma and allergies, including a dairy allergy that has changed from being very mild (coughing, occasional GI upset) to severe (swelling/itching throat immediately after dairy consumed) in that past 12 months and since the pregnancy I lost at 10 weeks last Fall, I've been diagnosed with allergic conjunctivitis which seems to flare up during my luteal phase (first instance was more mild and occurred during that pregnancy which ended after we'd seen baby's HB). The dairy allergy change and the conjunctivitis are new since we began TTC #2 and both came about after we'd already had the first 2 of our 6 losses spanning 2013-2014.
Current RE said it makes sense that the immune response is worse during luteal phase as progesterone suppresses our immune systems. My general doctor said it was ridiculous when I raised it months ago. Current RE wonders about natural killer (Nka) cells but discouraged the blood test as unreliable, with which I agree (and I'd like to avoid an endometrial biopsy for the moment) but has offered a protocol that would be used to treat overactive NKa cells. Intralipids are administered before transfer and then after a BFP I believe (the subsequent doses I need to clarify, my notes aren't clear on that).
RE also suggested a short course (6 days, low dose) of Medrol, a corticosteroid, for our next FET. I'd start before transfer and finish after transfer but before first beta. I'm wondering if that is too short to make a difference if my immune system is what's killing our babies?
Finally, he strongly suggested we stick with a natural FET again (the first one was the chemical noted above) rather than introducing more meds (to which my body may react less than favourably and so that we are our control is the addition of the intralipids and the Medrol). I was surprised by this but when he explained that the last time everything was working perfectly and he was very happy with my lining (it was only 7.6 two days before ovulation so I was less thrilled but he pointed to research which shows that is more than sufficient), I did not press the issue. Frankly, I'd prefer to avoid lupron as my body HATED it last time I did OE IVF.
I've researched a condition whereby moms of boys later have secondary recurrent pregnancy loss (SRM - secondary recurrent miscarriage seems to be the terminology). The theory is that the mothers bodies reject male babies due to the cells left in the moms' bodies after birthing the prior son(s). I can't seem to find much by way of a successful, proven treatment other than IVF with PGD to avoid male embryos being transferred.
We only have two frosties left (a day 6 early blast and a day 5 expanded blast, both AB if I recall correctly) and are not going to PGD them at this point. So even if I have this condition, I don't know what can be done about it.
If anyone has any experience with the recommended protocol I've noted (intralipids and short-course steroids) or ideas of other things I might ask the RE before we schedule another FET, I'd be most grateful. Thanks in advance!